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Wharton’s Jelly Mesenchymal Stem Cells
Stem cells

Researchers Review the “Biological Properties and Therapeutic Potential” of Wharton’s Jelly Mesenchymal Stem Cells (MSCs)

Researchers from Italy conducted a literature review of 83 articles about the biological properties and therapeutic potential of mesenchymal stem cells derived from Wharton’s Jelly of the human umbilical cord, and published the key learnings in 2019 in the International Journal of Stem Cells.1 The following is a summary of their findings. You can access the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657936/ Studies indicated WJ-MSCs could be used to treat:1-7 Neurological disorders Kidney injury Lung injury Orthopedic injury Liver injury Certain cancers The Following Properties Make WJ-MSCs Optimal Candidates for Allogenic Transplant1 WJ-MSCs have potent regenerative and immunomodulatory capabilities WJ-MSCs are capable of immune suppression and immune avoidance WJ-MSCs express very low levels of Human Leukocyte Antigen class I and zero expression of Human Leukocyte Antigen DR WJ-MSCs induce expansion of regulatory T cells and in vitro, do not generate immune responses from regulatory T cells WJ-MSCs produce tolerogenic Interluekin-10 and Transforming

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Stem cells

Is Michael Schumacher Receiving Stem Cell Treatment?

The French daily newspaper, Le Parisien, reported the Formula One legend, Michael Schumacher is receiving stem cell therapy at the Georges-Pompidou Hospital in Paris, France. Michael Schumacher suffered a traumatic brain injury after a devastating ski accident six years ago. Michael Schumacher, a retired German racing driver, is a seven-time Formula One champion, Ferrari’s most successful Formula One driver, and considered by many to be the greatest Formula One racer of all time. On December 29, 2013, Schumacher was skiing in the French Alps with his son when he sustained a traumatic brain injury after hitting his head on a rock. Following his injury, he underwent two surgeries and was put into a medically induced coma. Since 2014 he has been undergoing rehabilitation at his private residence. It has been reported that he is paralyzed and has difficulty communicating, but is slowly improving. What is Stem Cell Therapy? Stem cell

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Stem Cells for Cerebral Artery Ischemic Stroke
Stem cells

Clinical Trial Shows Human Umbilical Cord Blood to be Safe for the Treatment of Cerebral Artery Ischemic Stroke

A hallmark clinical study by physicians at Duke University and the University of Texas, published in Stem Cells Translational Medicine in 2018, showed IV infusion of human umbilical cord stem cells to be safe for the treatment of Cerebral Artery Ischemic Stroke.1 More than 85% of all strokes are ischemic strokes. Ischemic stroke is one of three types of stroke and occurs when the artery that supplies blood to the brain is blocked, reducing blood flow and oxygen to the brain. If blood circulation is not restored quickly, permanent brain damage occurs. Ischemic stroke can cause death or long-term disability and the only approved treatment is tissue plasminogen activator (tPA). TPA breaks up clots but to be effective it must be given within four hours from the start of the stroke and cannot be given after five hours. Additionally, it cannot be given to individuals with a history of hemorrhagic

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Cardiovascular

The Benefits of Allogeneic Mesenchymal Stem Cells for the Treatment of Cardiovascular and Neurodegenerative Disease

Mesenchymal stem cells are multipotent stromal cells that have the ability to differentiate, or become, a variety of cell types, including bone cells, cartilage cells, fat cells, and muscle cells. Mesenchymal stem cells (MSCs) are ideal for treating many kinds of injuries and disease, and can be derived from many different kinds of tissue including; bone marrow, adipose tissue, cord blood and cord tissue. Studies have been conducted using MSC derived from each of the different types of tissue and there is a lot of debate about what type of MSC is best for the treatment of different conditions. Most research has been conducted with MSCs derived from bone marrow and these cells have become the “gold standard” when discussing stem cell therapy. However, researchers are learning more everyday about the different properties of MSCs depending on what type of tissue they are derived from and there are many factors

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Rheumatoid Arthritis

Antibiotics May Increase the Risk of Rheumatoid Arthritis by 60%

Previous research has suggested that antibiotics may increase the risk of developing inflammatory bowel disease and autoimmune diseases such as type 1 diabetes and autoimmune liver disease, so researchers decided to asses if antibiotic use is associated with the onset of rheumatoid arthritis.1 Microbiota or bacteria, live in various parts of the human body including the skin (skin microbiota), the mouth (oral microbiota) and the intestinal tract (gut microbiota). Our intestines contain tens of trillions of microorganisms including more than 1000 different types of bacteria. These microorganisms play and integral part in keeping our metabolism and immune system functioning at its peak. Antibiotic usage can lead to a significant reduction in the type of microbial in our gut and the overall total number of microbials in our gut, directly impacting our metabolism and immune system. Study Results To evaluate if antibiotic use was associated with the development of rheumatoid arthritis

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Degenerative Spine Disease

Stem Cell Therapy: The Future for Degenerative Spine Disease

Degenerative disease of the lumbar spine is a primary cause of disability worldwide affecting at least 266 million people each year. Degenerative disease of the lumbar spine is an umbrella term used to describe different types of back pain including spondylolisthesis, spinal stenosis and disc degeneration.1,2 Degenerative disc disease in a condition in which damage to the spinal disc causes pain that can range from nagging to disabling and is the second leading cause of opioid prescriptions in the United States. For patients with severe degenerative disease, surgery may be considered as a treatment option, but surgery is invasive, risky, costly, and its effectiveness is unclear. For this reason, stem cell therapy is quickly becoming a preferred treatment option. Current Research The Stem Cells Transplant Institute in Costa Rica, recommends mesenchymal stem cells derived, cultured, and expanded from umbilical cord tissue, for the treatment of degenerative disc disease. A paper

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Stem cells

Wharton Jelly Stem Cells for the Treatment of Chronic Diabetic Skin Wounds

Results, of a study published in the Journal of Cosmetic Dermatology in May, 2019, showed human umbilical cord derived Wharton’s jelly mesenchymal stem cells can accelerate the repair and healing of chronic skin ulcers. Diabetic skin ulcers are painful, slow to heal, and require medical attention. Consistently high levels of blood sugar cause nerve and blood vessel damage, reduce circulation, and alter the skin’s structure causing harmless wounds to become open sores called diabetic ulcers. If left untreated, diabetic skin ulcers can become infected causing tissue death and ultimately require amputation. A diabetic ulcer is an open sore or wound and most commonly presents on the foot that does not progress through the normal healing process. Approximately 15% of patients with diabetes will develop a foot ulcer and approximately 6% of people will require hospitalization due to an infection or other wound related complication. Researchers at Shiraz University of Medical

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Stem cells

Benefits of Wharton’s Jelly Mesenchymal Stem Cells (MSCs) When Compared to Adipose or Bone Marrow Derived MSCs

Mesenchymal stem cells (MSCs) are adult stem cells that are able to differentiate into a wide variety of cell types. These cell types include bone, muscle, fat, cartilage, umbilical cord blood, and umbilical cord tissue. The benefits of MSCs are attributed primarily to the secretion of factors including cytokines and growth factors, which produce immunomodulatory and anti-inflammatory effects and stimulate angiogenesis. The gold standard tissue for mesenchymal stem cells has been bone marrow tissue, however, the results have been mixed and retrieving the stem cells from a patient’s own bone marrow is invasive and can be painful. Wharton’s jelly mesenchymal stromal (stem) cells are harvested from umbilical cord tissue and are considered by many regenerative experts to have the most potential for effective cell-based therapy with the added benefit of being far easier and less invasive to retrieve. Additional Benefits of Wharton’s jelly MSCs More abundant than both bone marrow

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Osteoporosis

Osteoporosis: Causes, Symptoms and Treatment with Stem Cells

Osteoporosis is commonly referred to as the “silent disease”, because bone loss can happen slowly over a long period of time without any warning symptoms, causing bones to become weak and brittle. Frequently people are not aware they have osteoporosis until they suffer from a broken bone, loss of height or develop a curve in their back causing them to hunch over. According to the National Osteoporosis Foundation, approximately 10 million Americans have osteoporosis and another 44 million Americans have osteopenia or low bone mass. (Find additional facts at: https://cdn.nof.org/wp-content/uploads/2015/12/Osteoporosis-Fast-Facts.pdf) Both men and women are at risk for osteoporosis. The likelihood of developing osteoporosis depends in part on how much bone mass you accumulate in your youth. Bone is a living tissue that is in a constant state of renewal. When you are young, your body makes new bone faster than it breaks old bone down and your bone mass

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Osteoarthritis

Knee and Hip Osteoarthritis Linked to Increased Risk of Death Due to Cardiovascular Disease

Researchers at Lund University in Sweden, published the results of a study showing there is a link between osteoarthritis (OA) and mortality due to cardiovascular disease.  The study was an epidemiological study designed to estimate cause-specific mortality in patients with OA compared to the general population. Study Design Researchers used a healthcare register to identify which residents of southern Sweden between the ages of 45 and 84 had been diagnosed with osteoarthritis in the peripheral joints between the years 1998 and 2003. They followed all residents of southern Sweden until the end of 2014 or until the resident moved or died. Using the death certificates, the cause of death was classified as; cardiovascular neoplasms, diabetes, infections, dementia, digestive disorders or other. Of the 469,000 residents of southern Sweden, 16,000 were diagnosed with arthritis of the knee, 9000 with arthritis of the hip, 4000 with arthritis of the wrist and 5,500

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Stem cells

Japan Approves Stem Cell Therapy for Spinal Cord Injury

Results, from a study at Sapporo Medical University in Japan, showed bone marrow derived stem cell therapy to be safe and effective for the treatment of spinal cord injury. Japan approves the first commercially produced stem cell product, Stemilac injection, for the treatment of spinal cord injuries. Stemilac was developed jointly by Nipro and Sapporo Medical University and is the world’s first approved marketed product for stem cell therapy, available only at the Sapporo Medical University in Sapporo, Japan. “This is an unprecedented revolution of science and medicine, which will open a new era of healthcare,” says oncologist Masanori Fukushima, head of the Translational Research Informatics Center, a Japanese government organization in Kobe that has been giving advice and support to the project for more than a decade. Weblio website Trial Design In an open-label trial, researchers in Japan evaluated autologous bone marrow derived stem cells in 13 patients who

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Lupus

Mesenchymal Stromal Stem Cells for the Treatment of SLE

Previous studies conducted in China have shown mesenchymal stromal stem cells have the potential to treat patients with lupus and the more severe SLE. However, the results seen in these trials are in patients of similar ethnic backgrounds. New results, of a proof-of-concept study conducted in Spain, were published in Lupus in October, 2018, and support the use of MSCs for the treatment of systemic lupus erythematosus (SLE) in patients with different ethnicities. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that occurs when your body’s immune system mistakenly attacks your own healthy tissues and organs. The Stem Cells Transplant Institute in Costa Rica, uses human umbilical cord mesenchymal stem cells (hUC-MSCs) for the treatment of systemic lupus erythematosus. Study Design The study, “Therapeutic potential of allogeneic mesenchymal stromal cells transplantation for lupus nephritis,” showed MSCs can control the symptoms of SLE in three patients of different ethnicities who were diagnosed

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Diabetes

Study Shows Women More Likely to Suffer from Diabetic Peripheral Neuropathy

A recent study, evaluating vitamin D deficiency in patients with diabetic peripheral neuropathy (DPN), found women are at significantly greater risk than men of suffering from peripheral neuropathy. Vitamin D is known as the sunshine vitamin because it is produced by the body in response to exposure to sunlight. The symptoms of vitamin D deficiency can be similar to the symptoms of peripheral neuropathy including; numbness, tingling, chronic pain, lack of coordination and falling, muscle weakness, and changes in blood pressure. Study Design With the similarity in symptoms, researchers hypothesized vitamin d deficiency may be associated with neuropathic pain in patients with DPN. Investigators enrolled 239 patients with type 2 diabetes. The cross-sectional study enrolled patients with type 2 diabetes from the outpatient endocrinology clinic at the King Abdullah University Hospital in Jordan, between January and December 2017. Researchers measure neuropathic pain, serum vitamin D levels, fasting blood glucose and

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Diabetes

High Healthcare Costs Associated with Diabetic Peripheral Neuropathy

Research results published in Neurology; Clinical Practice, found adult patients diagnosed with painful diabetic peripheral neuropathy, had the highest total health care costs across all aspects of healthcare, making diabetes the most-costly health condition in the United States. Diabetes is the number one cause of peripheral neuropathy damaging nerves in the arms, hands, feet, legs, and internal organs. Painful diabetic peripheral neuropathy affects up to one-third of patients diagnosed with diabetes and is associated with a significant reduction in overall quality of life, increased anxiety, depression, sleep disturbance, and difficulty walking. The purpose of the study published in May, 2019, was to “quantify healthcare resource utilization and risk of complications” in patients diagnosed painful diabetic peripheral neuropathy. https://cp.neurology.org/content/early/2019/05/24/CPJ.0000000000000671 Study Design Between January 2010 and December 2015, Adult patients diagnosed with diabetes or diabetic peripheral neuropathy were identified using MarketScan. (MarketScan is a health research database that includes commercial private medical

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Alzheimer’s disease

Chronic Inflammation; The Match That Lights Fire

Results from a study published in Neurology in March 2019, showed a link between systemic inflammation during the mid-life years, and memory loss and cognitive decline later in life.  Stem cell therapy at the Stem Cells Transplant Institute in Costa Rica may help improve the signs and symptoms of dementia by reducing inflammation by upregulating neuroprotective cytokines and decreasing pro-inflammatory cytokines. For years scientists have been trying to treat Alzheimer’s disease by focusing their efforts on treating or preventing two of the four key features of Alzheimer’s disease, the amyloid-beta plaques and neurofibrillary tangles, but they have not yet been successful at finding an effective treatment. Researchers decided to examine the long-term association between systemic inflammation and cognitive decline by evaluating data from the Atherosclerosis Risk in Communities (ARIC) study at Johns Hopkins University. https://n.neurology.org/content/92/11/e1256 Study design Researchers measured blood biomarkers including fibrinogen, white blood cell count, von Willebrand factor,

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Osteoarthritis

Study Finds Alarmingly High Rate of Opioid Use by Patients with Osteoarthritis

According to the National Institutes of Health, “every day more than 130 people in the United States die after overdosing on opioids”.1 and the Centers for Disease Control and Prevention estimate that opioid prescription abuse costs the United States approximately $78.5 billion dollars a year.2 In July of 2019, a group of international researchers from Sweden, Denmark and the UK published the results of a 12-month study conducted in the southern part of Sweden. The purpose of the study was to evaluate and quantify opioid use in patients with knee and hip osteoarthritis. Study Design Researchers included 751,579 Swedish patients, 35 years of age or older, diagnosed with knee or hip OA between the years 1998 and 2015. Using the Swedish Prescribed Drug Register, researchers evaluated how many of these people were prescribed opioid medication between November 1, 2014 and October 31, 2015.  Study Results Results showed almost one quarter

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Erectile Dysfunction

Erectile dysfunction: Impotence Rates More than Doubled in Last 25 Years

New data published by researchers from Kings College London shows up to up to half of men under 50 suffer from erectile dysfunction which is more than double the rate of impotence just 25 years ago. The team of researchers evaluated data from more than a dozen studies around the world, that included tens of thousands of participants ranging in age from late teens to adults in their 80s. The data from the combined studies showed that up to 50 percent of men under the age of 50 while one study conducted in Brazil found the condition occurred in almost 36 percent of men between the ages of 18 and 25, and almost 31 percent of men between the ages of 26 and 40. Researchers estimate by the year 2025, more than 322 million men will be affected by erectile dysfunction. Erectile dysfunction is the inability to get and/or keep

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Multiple Sclerosis

New Clinical Trials Supports Results of Previous Studies Showing Stem Cell Therapy to be a Safe and Effective Treatment for Patients with MS

A clinical trial published in January of this year, supported the results of previous studies, showing stem cell therapy to be a safe and effective treatment for patients with multiple sclerosis. Traditional, disease modifying treatment is able to reduce flare-ups and slow the progression of MS, however, this type of treatment in unable to repair the damage that has already occurred. The Stem Cells Transplant Institute recommends the use of stem cells derived from umbilical cord tissue for the treatment of multiple sclerosis. Summary of Study #1: ClinicalTrials.gov Identifier: NCT00273364 The first randomized clinical trial, published in JAMA, January 2019 showed stem cell therapy to be significantly better than current disease-modifying therapy for patients with active relapsing-remitting MS. Researchers, at the Feinberg School of Medicine at Northwestern Memorial Hospital in Chicago, enrolled 110 patients between September 2005 and July 2016. To qualify, Pptients had to have relapsing-remitting MS, at least 2

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Stem cells

How Does Stem Cell Therapy Work?

As the evidence of the clinical efficacy of stem cell therapy continues to grow, the physicians at the Stem Cells Transplant Institute receive hundreds of questions daily from people asking the same question: What happens to the stem cells once they are injected into the body?  There are 2 theories, that are not mutually exclusive: The undifferentiated stem cells arrive at the site of injury where they differentiate and become the type of cells specific to the tissue at that site. For example, when the stem cells reach the área of damaged cartilage, they differentiate into chondrocytes (the cells that form cartilage). Most adult tissue regenerates tissue naturally, however, it may not contain or regenerate a sufficient supply of cells to heal the injury or damage. Every person has a limited number of naturally occuring stem cells and the population of stem cells decreases due to age, environmental toxins and

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Stem cells

Regenerative Medicine: Which type of stem cells are best?

To understand which type of stem cell is best, it is necessary to dive a bit deeper into the science of stem cells and Regenerative Medicine. Regeneration is the ability of the human body to heal itself.  Regenerative medicine is the clinical application of regeneration. Two of the main sources of regenerative medicine are stem cells and growth factors, which stimulate and enhance stem cell and tissue regeneration. What are Stem cells? Stem cells are a type of undifferentiated cell that have the ability to differentiate, or change, into specific and specialized cell types. Adult stem cells are a type of undifferentiated cell found in a tissue or organ. It can renew itself and can differentiate into some or all of the major specialized cell types; replacing cells that are dying, and releasing molecules that enhance the repair of damaged tissue due to disease, trauma and aging. Two main characteristics

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Stem cells

Human Umbilical Cord Tissue Mesenchymal Stem Cells the New “Gold Standard” for Stem Cell Therapy

Regenerative medicine may be the best hope for patients with a chronic disability or disease. Stem cells are being used to treat neurological, cardiovascular, autoimmune and orthopedic conditions as well as spinal cord injuries, severe wounds, erectile dysfunction and the list goes on. Note: Despite all advances in stem cells research and the application of these therapies in many countries all over the world, stem cells therapies are not legally approved yet in San Diego, Los Angeles, Chicago, Dallas, New York, Jacksonville, Seattle, Houston, San Francisco, Salt Lake City, Miami, Beverly Hills and other US cities. However, stem cell treatments are legal in Costa Rica.

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Alzheimer’s disease

Vitamin C and Alzheimer’s Disease

Vitamin C, the vitamin we take to fight colds, and is needed for normal growth and development, plays a crucial role in cognitive function.  Researchers in Australia found patients with Alzheimer’s and dementia have lower blood levels of vitamin C than people with normal cognitive function.1 Note: Despite all advances in stem cells research and the application of these therapies in many countries all over the world, stem cells therapies are not legally approved yet in San Diego, Los Angeles, Chicago, Dallas, New York, Jacksonville, Seattle, Houston, San Francisco, Salt Lake City, Miami, Beverly Hills and other US cities. However, stem cell treatments are legal in Costa Rica.

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Cardiovascular

12 Common Causes of Erectile Dysfunction

Approximately 150 million men worldwide struggle with erectile dysfunction, and according the American Urological Association, it affects approximately 1 out of 2 men over the age of 50. Stem cell therapy at the Stem Cells Transplant Institute can help. Note: Despite all advances in stem cells research and the application of these therapies in many countries all over the world, stem cells therapies are not legally approved yet in San Diego, Los Angeles, Chicago, Dallas, New York, Jacksonville, Seattle, Houston, San Francisco, Salt Lake City, Miami, Beverly Hills and other US cities. However, stem cell treatments are legal in Costa Rica.

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Alzheimer’s disease

Alterations in the Brain May Occur as Early as 34 Years Before the Symptoms of Alzheimer’s Disease Appear

Researchers at Johns Hopkins School of Medicine found patients had increased levels of Tau, a biomarker of Alzheimer’s disease, as early as 34 years prior to the onset of symptoms.1 https://www.frontiersin.org/articles/10.3389/fnagi.2019.00074/full Note: Despite all advances in stem cells research and the application of these therapies in many countries all over the world, stem cells therapies are not legally approved yet in San Diego, Los Angeles, Chicago, Dallas, New York, Jacksonville, Seattle, Houston, San Francisco, Salt Lake City, Miami, Beverly Hills and other US cities. However, stem cell treatments are legal in Costa Rica.

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Osteoarthritis

Have Scientists Uncovered the Underlying Cause of Osteoarthritis (OA)?

Osteoarthritis may be caused by an abnormal or impaired immune system. Scientists at Stanford University School of Medicine have definitively linked mast cells to the development of osteoarthritis. A mast cell, also know as a mastocyte, are located in connective tissue including in bone marrow, the skin, the gastrointestinal tract and other sites. They are part of the immune system and play a critical role in helping defend tissue from disease. https://elifesciences.org/articles/39905 Note: Despite all advances in stem cells research and the application of these therapies in many countries all over the world, stem cells therapies are not legally approved yet in San Diego, Los Angeles, Chicago, Dallas, New York, Jacksonville, Seattle, Houston, San Francisco, Salt Lake City, Miami, Beverly Hills and other US cities. However, stem cell treatments are legal in Costa Rica.

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Neuropathy

Peripheral Neuropathy Shown to Impair Driving Performance

Researchers in the United Kingdom found peripheral neuropathy impaired a motorist’s ability to drive a car and put the driver at greater risk of losing control of his or her vehicle.1 The good news is, with practice, the drivers were able to improve their skills. https://onlinelibrary.wiley.com/doi/full/10.1111/dme.13957 Note: Despite all advances in stem cells research and the application of these therapies in many countries all over the world, stem cells therapies are not legally approved yet in San Diego, Los Angeles, Chicago, Dallas, New York, Jacksonville, Seattle, Houston, San Francisco, Salt Lake City, Miami, Beverly Hills and other US cities. However, stem cell treatments are legal in Costa Rica.

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Stem cells

Transplanted bone marrow-derived endothelial stem cells delay the progression of ALS

According to a report, published by researchers from the University of South Florida on March 27, in Scientific Reports, transplantation of human bone marrow-derived endothelial progenitor cells (EPCs) into mice with similar symptoms of amyotrophic lateral sclerosis (ALS) helped more motor neurons survive and slowed disease progression by repairing damage to the blood-spinal cord barrier (BSCB). Note: Despite all advances in stem cells research and the application of these therapies in many countries all over the world, stem cells therapies are not legally approved yet in San Diego, Los Angeles, Chicago, Dallas, New York, Jacksonville, Seattle, Houston, San Francisco, Salt Lake City, Miami, Beverly Hills and other US cities. However, stem cell treatments are legal in Costa Rica.

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Diabetes

Could Stem Cells Cure Diabetes?

With proper care and treatment, diabetes is manageable, but no cure is yet available for this disease. Transforming stem cells into insulin-secreting cells may be the answer to finally curing diabetes. Note: Despite all advances in stem cells research and the application of these therapies in many countries all over the world, stem cells therapies are not legally approved yet in San Diego, Los Angeles, Chicago, Dallas, New York, Jacksonville, Seattle, Houston, San Francisco, Salt Lake City, Miami, Beverly Hills and other US cities. However, stem cell treatments are legal in Costa Rica.

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Frailty

Why injured bones do not heal as well with age?

A study published on March 18, 2019, by the Proceedings of the National Academy of Sciences (PNAS), found that increases in chronic inflammation, not the passage of time, is the main reason why injured bones do not heal as well with age. Note: Despite all advances in stem cells research and the application of these therapies in many countries all over the world, stem cells therapies are not legally approved yet in San Diego, Los Angeles, Chicago, Dallas, New York, Jacksonville, Seattle, Houston, San Francisco, Salt Lake City, Miami, Beverly Hills and other US cities. However, stem cell treatments are legal in Costa Rica.

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