Stem Cell Therapy for Spinal Cord Injury (SCI)

At Stem Cells Transplant Institute in Costa Rica, we offer personalized stem cell therapy programs for spinal cord injury designed to support neurological function, mobility, and the body’s natural recovery processes through regenerative medicine approaches.

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What Is a Spinal Cord Injury?

A spinal cord injury occurs when trauma or disease damages the spinal cord and disrupts communication between the brain and the rest of the body.

Depending on the level and severity of the injury, this interruption can lead to partial or complete loss of movement, sensation, and autonomic function below the affected area. Although surgical care and rehabilitation can support stabilization and recovery, there is currently no treatment capable of fully reversing established spinal cord damage. Cells within the central nervous system have limited capacity for regeneration, which is why long-term symptoms may persist.

According to the World Health Organization (WHO, 2023),  250,000 to 500,000 people worldwide experience a spinal cord injury each year.

Why Seek Stem Cell Therapy for Spinal Cord Injury in Costa Rica?

Stem cell therapy for Spinal Cord Injury is offered at the Stem Cells Transplant Institute in San José, Costa Rica, within a certified clinical facility operating under structured protocols and physician supervision. Programs are designed to accommodate patients across different injury levels and stages of recovery.

Traveling internationally with a spinal cord injury is not a simple undertaking. Pre-travel coordination covers wheelchair accessibility, transfer logistics, attendant care needs, and any respiratory or urological considerations relevant to the patient’s injury level. Patients from the United States, Canada, and Europe choose Costa Rica because the facility is equipped for patients with significant physical limitations, the team has experience across cervical, thoracic, and lumbar profiles, and the cost difference compared to equivalent programs in North America is substantial.

Comprehensive pre-treatment planning includes both clinical and logistical coordination. This process may involve: Injury classification, injury level, time since injury, and current neurological baseline, Review of respiratory, urological, and mobility-related considerations, and planning for accessibility, transfer needs, and caregiver support during travel. Treatment protocols are individualized based on injury characteristics and stage of recovery.

Common characteristics

  • Partial or complete paralysis (paraplegia or tetraplegia)
  • Loss of sensation below the injury site
  • Muscle spasms or neuropathic pain
  • Impaired bladder or bowel control
  • Difficulty breathing or regulating blood pressure
  • Changes in balance and coordination
Evidence-Based Treatment

Why Stem Cell Therapy for Spinal Cord Injury?

Research suggests that mesenchymal stem cells (MSCs) can migrate towards areas of spinal cord injury and release protective signals that help modulate inflammation and support tissue stability. These signals may contribute to creating a healthier environment for healing by reducing secondary injury and supporting the natural processes involved in nerve protection and repair.

MSCs have been studied for their potential to limit scarring, promote blood vessel formation, and support the survival of existing nerve cells. By influencing these pathways, stem cell therapy may complement rehabilitation and standard medical care for selected patients living with SCI.

Internationally, MSC-based therapies for spinal cord injury continue to be investigated. In Japan, one MSC product has received conditional, time-limited approval under the country’s regenerative medicine framework for use in selected cases of SCI.

Overall, current evidence remains preliminary and ongoing clinical trials are required to confirm the consistency, magnitude, and long-term impact of these effects.

1

Modulating Inflammation at the Injury Site

MSCs secrete cytokines and growth factors that help calm excessive inflammation surrounding the injured spinal cord. By reducing secondary inflammatory damage, MSCs may support a more stable environment for tissue preservation.
(Frontiers in Neurology, 2022)

2

Supporting Nerve Cell Survival and Protective Pathways

MSCs secrete natural healing proteins such as BDNF (Brain-Derived Neurotrophic Factor) and NGF (Nerve Growth Factor)—which can help protect vulnerable nerve cells, support their survival, and maintain healthier conditions for neural signaling.
(Cell Transplantation, 2021)

3

Modulating Scar Tissue Formation

Following SCI, glial scar tissue can form and may interfere with nerve communication. MSC therapy may influence the cellular processes involved in scar formation, potentially helping maintain a more favorable environment for neural activity.
(Stem Cells Translational Medicine, 2023)

Icono minimalista de un cerebro humano de color púrpura que destaca la división entre los dos hemisferios cerebrales sobre un fondo negro sólido.
4

Promoting Blood Flow and Tissue Support

MSCs can stimulate angiogenesis— the formation of new blood vessels— which helps deliver oxygen and nutrients to damaged areas. By supporting local blood flow and reducing tissue stress, MSCs may contribute to healthier spinal cord conditions.
(Regenerative Medicine, 2022)

5

Enhancing the Overall Microenvironment

Rather than replacing damaged neurons, MSCs primarily act by modulating the biological environment around the injury. Their paracrine signals can reduce cellular stress, stabilize surrounding tissues, and support natural processes involved in recovery.
(Cell Transplantation, 2021)

Expected Benefits and Clinical Observations

Although individual responses vary widely, published studies and clinical observations have reported potential supportive improvement in the following functional domains:

Movement control
20-40%
Sensory function
25-45%
Bladder-bowel control
15-35%
Spasms or neuropathic pain
20-40%
Overall independence
25-50%
Icono morado de una cara sonriente rodeada de tres signos de más, simbolizando positividad, mejora continua y bienestar.

*These percentages summarize ranges reported in selected clinical studies and observational cohorts under controlled conditions and standardized outcomes measures. They are not specific to any single study or to treatments performed at Stem Cells Transplant Institute. They should not be interpreted as averages, promises, or guaranteed results for individual patients. Evidence for MSC therapy in spinal cord injuries remains preliminary, and ongoing controlled clinical trials are still evaluating the magnitude, durability and consistency of these effects. All observations should be considered exploratory and hypothesis-generating rather than definitive proofs of efficacy.

Timeline of Reported Improvements

 Published studies and patient-reported outcomes suggest that improvements following mesenchymal stem cell therapy for SCI may develop gradually over time. These timelines are illustrative summaries rather than predictions, and individual responses vary significantly.

1-3 months
Reduced inflammation and muscle spasms
3-6 months
Gradual return of motor or sensory function in some cases
6-12 months
Continued strengthening, improved coordination or functional independence have been observed in selected cases

*These timelines summarize patterns reported across selected published studies and observational cohorts. They are not specific predictions, and they do not represent expected outcomes for any individual patient. Individual experiences vary considerably, and some patients may experience minimal or no improvement. Evidence for MSC therapy in spinal cord injuries remains preliminary, and larger controlled clinical trials are needed to validate these observations. All timelines should be interpreted as exploratory and non-confirmatory.

Patient Stories & Testimonials

Meet some of the patients who have trusted our team with their regenerative medicine treatment.

Individual experiences vary. These testimonials describe personal experiences with our team and process.

Key Research Studies

Mesenchymal Stem Cell Therapy for Spinal Cord Injury: Network Meta-Analysis

Frontiers in Cellular Neuroscience • 2025

Systematic review and network meta-analysis evaluating therapeutic effectiveness and safety of mesenchymal stem cell therapy for spinal cord injury.

View published study

MSC Transplantation for Spinal Cord Injury

Journal of Translational Medicine • 2021

Systematic review analyzing clinical outcomes and comparative efficacy of mesenchymal stem cell transplantation for spinal cord injury.

View published study

Current Status of MSC Therapy in Spinal Cord Injury

Spine Surgery and Related Research • 2023

Scientific review describing clinical progress, therapeutic potential, and future directions of mesenchymal stem cell therapy for spinal cord injury.

View published study

Mechanisms and Prospects of MSC Therapy in Spinal Cord Injury

Frontiers in Cellular Neuroscience • 2022

Research review explaining cellular mechanisms and neuroregenerative pathways involved in mesenchymal stromal cell therapy for spinal cord injury.

View published study

Combined Stem Cell Transplantation for Acute Spinal Cord Injury

Stem Cell Research & Therapy • 2024

Experimental study demonstrating improved neuroregeneration and reduced neuroinflammation following combined stem cell transplantation therapy.

View published study

Reviewed by

Picture of Dr Heidy Chaves
Dr Heidy Chaves

Regenerative Medicine Specialist | Stem Cells Transplant Institute

Dr. Heidy Chaves is a dedicated physician specializing in regenerative medicine. She earned her medical degree from Universidad de Ciencias Médicas (UCIMED) and pursued advanced training in aesthetic medicine in Spain and hair transplantation in Greece. She holds multiple international certifications in regenerative therapies and life support.

Location

San José, Costa Rica

Contact Us

info@stemcellstransplantinstitute.com

Call US

+1 888 785-4170

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