Stem Cell Therapy for Spinal Cord Injury (SCI)

At the Stem Cells Transplant Institute in Costa Rica, we offer advanced stem cell therapy for spinal cord injury to support healing, improve mobility, and enhance recovery through personalized regenerative treatment programs.

Reviewed: 19 Apr 2026

What Is a Spinal Cord Injury?

A spinal cord injury occurs when trauma or disease damages the spinal cord and disrupts communication between the brain and the rest of the body.

Depending on the level and severity of the injury, this interruption can lead to partial or complete loss of movement, sensation, and autonomic function below the affected area. Although surgical care and rehabilitation can support stabilization and recovery, there is currently no treatment capable of fully reversing established spinal cord damage. Cells within the central nervous system have limited capacity for regeneration, which is why long-term symptoms may persist.

According to the World Health Organization (WHO, 2023),  250,000 to 500,000 people worldwide experience a spinal cord injury each year.

Why Seek Stem Cell Therapy for Spinal Cord Injury in Costa Rica?

Stem cell therapy for Spinal Cord Injury is offered at the Stem Cells Transplant Institute in San José, Costa Rica, within a certified clinical facility operating under structured protocols and physician supervision. Programs are designed to accommodate patients across different injury levels and stages of recovery.

Traveling internationally with a spinal cord injury is not a simple undertaking. Pre-travel coordination covers wheelchair accessibility, transfer logistics, attendant care needs, and any respiratory or urological considerations relevant to the patient’s injury level. Patients from the United States, Canada, and Europe choose Costa Rica because the facility is equipped for patients with significant physical limitations, the team has experience across cervical, thoracic, and lumbar profiles, and the cost difference compared to equivalent programs in North America is substantial.

Comprehensive pre-treatment planning includes both clinical and logistical coordination. This process may involve: Injury classification, injury level, time since injury, and current neurological baseline, Review of respiratory, urological, and mobility-related considerations, and planning for accessibility, transfer needs, and caregiver support during travel. Treatment protocols are individualized based on injury characteristics and stage of recovery.

Common characteristics

  • Partial or complete paralysis (paraplegia or tetraplegia)
  • Loss of sensation below the injury site
  • Muscle spasms or neuropathic pain
  • Impaired bladder or bowel control
  • Difficulty breathing or regulating blood pressure
  • Changes in balance and coordination
Evidence-Based Treatment

Why Stem Cell Therapy for Spinal Cord Injury?

Research suggests that mesenchymal stem cells (MSCs) can migrate towards areas of spinal cord injury and release protective signals that help modulate inflammation and support tissue stability. These signals may contribute to creating a healthier environment for healing by reducing secondary injury and supporting the natural processes involved in nerve protection and repair.

MSCs have been studied for their potential to limit scarring, promote blood vessel formation, and support the survival of existing nerve cells. By influencing these pathways, stem cell therapy may complement rehabilitation and standard medical care for selected patients living with SCI.

Internationally, MSC-based therapies for spinal cord injury continue to be investigated. In Japan, one MSC product has received conditional, time-limited approval under the country’s regenerative medicine framework for use in selected cases of SCI.

Overall, current evidence remains preliminary and ongoing clinical trials are required to confirm the consistency, magnitude, and long-term impact of these effects.

1

Modulating Inflammation at the Injury Site

MSCs secrete cytokines and growth factors that help calm excessive inflammation surrounding the injured spinal cord. By reducing secondary inflammatory damage, MSCs may support a more stable environment for tissue preservation.
(Frontiers in Neurology, 2022)

2

Supporting Nerve Cell Survival and Protective Pathways

MSCs secrete natural healing proteins such as BDNF (Brain-Derived Neurotrophic Factor) and NGF (Nerve Growth Factor)—which can help protect vulnerable nerve cells, support their survival, and maintain healthier conditions for neural signaling.
(Cell Transplantation, 2021)

3

Modulating Scar Tissue Formation

Following SCI, glial scar tissue can form and may interfere with nerve communication. MSC therapy may influence the cellular processes involved in scar formation, potentially helping maintain a more favorable environment for neural activity.
(Stem Cells Translational Medicine, 2023)

Icono minimalista de un cerebro humano de color púrpura que destaca la división entre los dos hemisferios cerebrales sobre un fondo negro sólido.
4

Promoting Blood Flow and Tissue Support

MSCs can stimulate angiogenesis— the formation of new blood vessels— which helps deliver oxygen and nutrients to damaged areas. By supporting local blood flow and reducing tissue stress, MSCs may contribute to healthier spinal cord conditions.
(Regenerative Medicine, 2022)

5

Enhancing the Overall Microenvironment

Rather than replacing damaged neurons, MSCs primarily act by modulating the biological environment around the injury. Their paracrine signals can reduce cellular stress, stabilize surrounding tissues, and support natural processes involved in recovery.
(Cell Transplantation, 2021)

Expected Benefits and Clinical Observations

Although individual responses vary widely, published studies and clinical observations have reported potential supportive improvement in the following functional domains:

Movement control
20-40%
Sensory function
25-45%
Bladder-bowel control
15-35%
Spasms or neuropathic pain
20-40%
Overall independence
25-50%
Icono morado de una cara sonriente rodeada de tres signos de más, simbolizando positividad, mejora continua y bienestar.

*These percentages summarize ranges reported in selected clinical studies and observational cohorts under controlled conditions and standardized outcomes measures. They are not specific to any single study or to treatments performed at Stem Cells Transplant Institute. They should not be interpreted as averages, promises, or guaranteed results for individual patients. Evidence for MSC therapy in spinal cord injuries remains preliminary, and ongoing controlled clinical trials are still evaluating the magnitude, durability and consistency of these effects. All observations should be considered exploratory and hypothesis-generating rather than definitive proofs of efficacy.

Timeline of Reported Improvements

 Published studies and patient-reported outcomes suggest that improvements following mesenchymal stem cell therapy for SCI may develop gradually over time. These timelines are illustrative summaries rather than predictions, and individual responses vary significantly.

1-3 months
Reduced inflammation and muscle spasms
3-6 months
Gradual return of motor or sensory function in some cases
6-12 months
Continued strengthening, improved coordination or functional independence have been observed in selected cases

*These timelines summarize patterns reported across selected published studies and observational cohorts. They are not specific predictions, and they do not represent expected outcomes for any individual patient. Individual experiences vary considerably, and some patients may experience minimal or no improvement. Evidence for MSC therapy in spinal cord injuries remains preliminary, and larger controlled clinical trials are needed to validate these observations. All timelines should be interpreted as exploratory and non-confirmatory.

Patient Stories & Testimonials

Frequently Asked Questions

SCTI uses mesenchymal stem cells (MSCs) derived from ethically sourced umbilical cord tissue. These cells are selected for their ability to release biological signals that may help modulate inflammation, support tissue stability, and create a more favorable environment for healing.

 Your physician will explain the recommended administration route – such as IV infusion or, when clinically appropriate, intrathecal injection – and how it may support your overall care plan.

Pricing varies depending on the severity of the injury, the number of stem cell applications recommended, and the supportive therapies included. 

After reviewing your medical history, SCTI will provide a personalized treatment plan with a clear, upfront cost breakdown before moving forward.

Most SCI patients stay 7–10 days, which allows time for evaluation, treatment administration, and short-term follow-up. 

If multiple sessions or additional supportive therapies are needed, your patient coordinator will help arrange the ideal treatment schedule and travel plan.

Stem cell therapy cannot guarantee regeneration or restored function, but some clinical studies—including early research from Japan where a MSC product is conditionally approved—have reported improvements in certain patients, but outcomes vary widely. 

Whether you may benefit depends on your specific injury characteristics, overall health, and rehabilitation program. Your doctor will help set realistic expectations for your case.

Treatment is typically performed through IV infusion and, when appropriate, intrathecal (spinal) injection. These are minimally invasive procedures designed to minimize discomfort and downtime. Surgery is not typically required for the stem cell application itself.

Yes. Physical therapy is often encouraged as part of a comprehensive recovery plan. Combining rehabilitation with stem cell therapy may help support overall mobility and functional stability by taking advantage of the healthier biological environment MSCs help create.

Your medical team will guide you on timing, activity levels, and the most appropriate rehabilitation approach for your specific condition.

MSC therapy is generally well tolerated, and most patients experience only mild, short-term effects such as fatigue, headache, or low-grade fever.

As with any medical procedure, more serious complications are possible but uncommon. Every patient undergoes a thorough medical evaluation to ensure the treatment is appropriate, and emergency support is available on-site if needed.

Key Research Studies

Mesenchymal Stem Cell Therapy for Spinal Cord Injury: Network Meta-Analysis

Frontiers in Cellular Neuroscience • 2025

Systematic review and network meta-analysis evaluating therapeutic effectiveness and safety of mesenchymal stem cell therapy for spinal cord injury.

View published study

MSC Transplantation for Spinal Cord Injury

Journal of Translational Medicine • 2021

Systematic review analyzing clinical outcomes and comparative efficacy of mesenchymal stem cell transplantation for spinal cord injury.

View published study

Current Status of MSC Therapy in Spinal Cord Injury

Spine Surgery and Related Research • 2023

Scientific review describing clinical progress, therapeutic potential, and future directions of mesenchymal stem cell therapy for spinal cord injury.

View published study

Mechanisms and Prospects of MSC Therapy in Spinal Cord Injury

Frontiers in Cellular Neuroscience • 2022

Research review explaining cellular mechanisms and neuroregenerative pathways involved in mesenchymal stromal cell therapy for spinal cord injury.

View published study

Combined Stem Cell Transplantation for Acute Spinal Cord Injury

Stem Cell Research & Therapy • 2024

Experimental study demonstrating improved neuroregeneration and reduced neuroinflammation following combined stem cell transplantation therapy.

View published study
info
Location

San José, Costa Rica

Contact Us

info@stemcellstransplantinstitute.com

Call Center

+1 888 785-4170

APPLY TODAY