Type 1 Diabetes Mellitus

Diabetes mellitus is a group of diseases that causes a person to have high levels of sugar (glucose) in the blood or, hyperglycemia. The two most common forms of diabetes are type 1 and type 2.

Patients with type 1 diabetes do not produce insulin. Type 1 diabetes mellitus is a life-long disease that requires daily insulin injections and can lead to other serious medical complications.  

Treatment at the Stem Cells Transplant Institute could help improve the following symptoms of type I diabetes:

  • Excessive thirst
  • Frequent Urination
  • Excessive hunger
  • Fatigue
  • Blurred Vision
  • Unexplained weight loss
  • Irritability
  • Frequent infections
  • Slow healing sores (e.g. gum infections, vaginal infections)
  • Dizziness

What is type 1 diabetes?

The incidence, of the chronic and devastating disease of type 1 diabetes, has been rising at a rapid rate.1

Approximately 10% of diabetes cases are type 1.

Patients with type 1 diabetes do not produce insulin but the cause is unknown. Normally the immune system produces antibodies which protect the body from foreign invaders such as; viruses, bacteria and germs. In patients with type 1 diabetes, the immune system mistakenly attacks and destroys the healthy insulin-producing beta cells in the pancreas.

The result is little or no insulin to transport the sugar into cells.  Sugar builds up in the blood stream causing systemic damage.

The symptoms of type 1 diabetes can present suddenly and at any age, but most patients with type 1 diabetes are diagnosed in early childhood or adolescence. Symptoms might include; excessive urination, thirst, constant hunger, unexplained weight loss, changes in vision, and fatigue.

Serious complications caused by type 1 diabetes2-4:

  • Organ damage including damage to the heart, kidneys, eyes, blood vessels and nerves
  • Heart attack and/or stroke
  • Foot ulcers, infection and limb amputation
  • Blindness
  • Kidney failure

Why should I consider stem cell therapy?

Researchers have shown mesenchymal stem cells have the potential to treat many chronic diseases, including type 1 diabetes. Mesenchymal stem cells have the ability to:

Differentiate

Self-renew

Suppress the immune system

Reduce inflammation

Repair tissue

In type 1 diabetes, mesenchymal stem cells can help stop beta cell destruction and preserve beta cell function and mass.1,5

Mesenchymal stem cells can modulate a patient’s immune system so that it no longer mistakenly attacks the beta cells and can also repair damaged beta cells. The patient’s new beta cells will function appropriately, correctly control blood sugar levels.

Preliminary results from one clinical trial showed the effect on the immune system by mesenchymal stem cells allowed beta cells to regenerate and improve glycemic control in patients with long-standing type 1 diabetes.6 After treatment, a patient will notice continuous improvement over time.

What is the treatment protocol for type 1 diabetes at the Stem Cells Transplant Institute?

For optimal results. the Stem Cells Transplant Institute recommends the use of human umbilical cord mesenchymal stem cells (hUC-MSCs) for the treatment of type 1 diabetes. Treatment includes:

  • 1cc vial of 30 million mesenchymal stem cells derived from human umbilical cord blood
  • Antioxidant therapy with vitamin C and glutathione
  • Ozone therapy
  • Platelet-rich plasma therapy (PRP)

What are the advantages of human umbilical cord mesenchymal stem cells?

  • Abundant supply containing up to 10 times more stem cells than bone marrow or adipose derived stem cells
  • hUC-MSC have immunosuppressors and immunomodulatory properties that allow their use in any individual without rejection- Human Leukocyte Antigen (HLA) matching is not necessary
  • Greater proliferation ability than adult autologous stem cells
  • They regenerate at a very rapid rate
  • They are young and very adaptive
  • They have not been impacted by the aging process
  • They have not been affected by environmental toxins
  • Umbilical cord stem cells can be administered multiple times over the course of days
  • Eliminates the need to collect stem cells from the patient’s fat or hip bone reducing pain and recovery time

What are the challenges?

Using stem cells to control the patient’s immune system is challenging. In some trials when beta cells were created or transplanted into a patient, their immune system would continue to target and destroy the new cells.

Scientists are researching ways to better protect the new beta cells from future destruction.

Stem Cells Collected

How are the stem cells collected?

We use only umbilical cord stem cells that are derived exclusively from umbilical cord donations. 

The umbilical cord stem cells from are collected after informed consent has been given by the parent, or parents, and only after the delivery of the baby.

The collection follows strict ethical protocols ensuring the stem cells are from safe, reliable sources using a non-invasive, simple and painless procedure. Once collected, the cord blood is then screened for

How are the stem cells administered?

The stem cells are administered intravenously.

About the Stem Cells Transplant Institute

Costa Rica has one of the best healthcare systems in world and is ranked among the highest for medical tourism. Using the most advanced technologies, the team of experts at The Stem Cells Transplant Institute believes in the potential of stem cell therapy for the treatment of diabetes. We are committed to providing personalized service and the highest quality of care to every patient.

Scientific References:

  1. Ezquer et al., J Stem Cell Res Ther 2014, 4:8 Mesenchymal Stem Cell Therapy in Type 1 Diabetes Mellitus and Its Main Complications: From Experimental Findings to Clinical Practice.
  2. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Emerging Risk Factors Collaboration. Sarwar N, Gao P, Seshasai SR, Gobin R, Kaptoge S, Di Angelantonio et al. Lancet. 2010; 26;375:2215-2222.
  3. Causes of vision loss worldwide, 1990-2010: a systematic analysis. Bourne RR, Stevens GA, White RA, Smith JL, Flaxman SR, Price H et al. Lancet Global Health 2013;1:e339-e349
  4. 2014 USRDS annual data report: Epidemiology of kidney disease in the United States. United States Renal Data System. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 2014:188–210.
  5. Concise Review: Mesenchymal Stem Cell Treatment of the Complications of Diabetes Mellitus. VLADISLAV VOLAREVIC STEM CELLS 2011;29:5–10 6. Zhao Y., New Hope for Diabetics: Adult Blood Stem Cells Can Make Insulin. Discovery Medicine.July, 28, 2009.