The Stem Cells Transplant Institute in Costa Rica, uses human umbilical cord mesenchymal stem cells (hUC-MCSCs) for the treatment of rheumatoid arthritis.
Treatment with stem cells is a very promising approach for the treatment of different autoimmune disorders such as rheumatoid arthritis and could help improve the symptoms of RA:
Rheumatoid arthritis is a chronic inflammatory disease that primarily affects the joints, causing destruction of the articular cartilage resulting in; pain, stiffness, and inflammation of the synovial membrane.
The immune system is designed to protect healthy tissue from foreign invaders such as; bacteria, viruses, and germs however, rheumatoid arthritis occurs when the immune system mistakenly attacks the synovium, the healthy tissue membrane that surrounds the joints.
This results in inflammation that thickens the synovium, eventually destroying the cartilage and bone within the joint.
As the joint is destroyed the tendons and ligaments holding the join together are damaged and the joint is no longer supported.
In approximately 40% of people diagnosed with rheumatoid arthritis, the inflammation caused by the disorder, can affect more than just the joints. It can also affect non-joint structures such as the; skin, eyes, kidneys, blood vessels, nerve tissue, bone marrow, heart, and lungs.
The exact cause of the disease is unknown but researchers believe it is a combination of genetic and environmental causes.
Rheumatoid arthritis increases your risk of other serious health problems including:
Despite advances in FDA approved treatments the following problems remain:
The Stem Cells Transplant Institute recommends the use of hUC-MSCs for the treatment of RA. For optimal results, we recommend a two-day treatment. Each day you will receive the following:
We use only umbilical cord stem cells that are derived exclusively from umbilical cord donations.
The umbilical cord stem cells from are collected after informed consent has been given by the parent, or parents, and only after the delivery of the baby.
The collection follows strict ethical protocols ensuring the stem cells are from safe, reliable sources using a non-invasive, simple and painless procedure.
Once collected, the cord blood is then screened for disease.
Stem cells are administered locally into the affected joint(s) and intravenously.
Costa Rica has one of the best healthcare systems in world and is ranked among the highest for medical tourism.
Using the most advanced technologies, the team of experts at The Stem Cells Transplant Institute believes in the potential of stem cell therapy for the treatment of autoimmune diseases.
We are committed to providing personalized service and the highest quality of care to every patient.
1.Xin Yan, Yurong, Cen, Qin Wang. Mesenchymal stem cells alleviate experimental rheumatoid arthritis through microRNA-regulated IκB expression. Scientific Reports | 6:28915 | DOI: 10.1038/srep28915 (2016)
2.Straub, R. H. Rheumatoid arthritis: Stress in RA: a trigger of proinflammatory pathways? Nat Rev Rheumatol 10, 516–518
3.De Bari. Are mesenchymal stem cells in rheumatoid arthritis the good or bad guys? Arthritis Research & Therapy (2015) 17:113
4.A.G. Kay et al. Chapter 8 Mesenchymal Stem Cell Therapy in Rheumatoid ArthritisP. Van Pham (ed.), Bone and Cartilage Regeneration, Stem Cells in Clinical Applications,149-176.
5.Iyer SS, Rojas M. Anti-infl ammatory effects of mesenchymal stem cells: novel concept for future therapies. Expert Opin Biol Ther. 2008;8(5):569–81.
6.Alvaro-Gracia JM, Jover JA, Garcia-Vicuña R, Carreño L, Alonso A, Marsal S, et al. Phase IB/Iia study on intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis patients (abstract). Arthritis Rheum. 2013;65(Suppl 10):2644. doi:10.1002/art.2013.65.issue-s10.
7.Wang L, et al. Human umbilical cord mesenchymal stem cell therapy for patients with active rheumatoid arthritis: safety and efficacy. Stem Cells Dev. 2013;22(24):3192–202. doi:10.1089/ scd.2013.0023.