Stem Cells Therapy
Diabetic Autonomic Neuropathy (DAN)

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Diabetic neuropathies are characterized by damage to the nerves. There are four types of neuropathy; peripheral, proximal, focal, and autonomic. Autonomic neuropathy occurs when nerves that control the heart and circulation are damaged.

Treatment at the Stem Cells Transplant Institute could help improve the symptoms of autonomic neuropathy including:

What is diabetic autonomic neuropathy?

Autonomic neuropathy is a result of damage to the nerves that carry information from the brain and spinal cord; to the heart, blood vessels, bladder, intestines and sweat glands. At one time, DAN was considered rare, but a publication in 2014 showed the rates may be as high as 90% in patients with type 1 diabetes and 70% in patients with type 2 diabetes.

Autonomic nerve damage can also be caused by other conditions including:

Treatment to reverse nerve damage is typically not possible. Current treatment options can be complicated, involving medication, lifestyle changes and possibly surgery and focus only on managing your symptoms and preventing further problems. How well you do will depend on the cause of the problem

Can stem cell therapy improve the signs and symptoms of aging?How can stem cell therapy improve the symptoms of autonomic neuropathy?

There is no cure for neuropathy and currently available therapeutic approaches only treat the symptoms of the disease.

Mesenchymal stem cells produce;

  1. proteins that support the growth and survival of neurons
  2. angiogenic factors that are essential for the healing, growth, development, and maintenance of blood vessels
  3. immunomodulatory substances that can reverse the damage to the nerves2,3 

Researchers evaluated the use of mesenchymal stem cells to treat Multiple system atrophy (MSA), a progressive neurodegenerative disorder characterized by a combination of symptoms that affect both the autonomic nervous system and movement.

MSA is a devastating disease with an average life expectancy of only 9 years after diagnosis. The study demonstrated that MSC therapy in patients with MSA was safe and delayed the progression of neurological deficits with achievement of functional improvement and improved quality of life during the12 month follow up.4

MSCs improve diabetic cardiac autonomic neuropathy

“MSC administration promoted density of sympathetic and parasympathetic nerves in the ventricular myocardium of diabetic rats, increased the ratio of parasympathetic to sympathetic nerve fibers, and suppressed ventricular arrhythmia inducibility.5”

What is the treatment protocol for autonomic neuropathy at the Stem Cells Transplant Institute?

The Stem Cells Transplant Institute recommends the use of hUC-MSCs for the treatment of diabetic neuropathy. Treatment includes:

  1. 1cc vial of 30 million mesenchymal stem cells derived from human umbilical cord blood
  2. Antioxidant therapy with vitamin C and glutathione
  3. Ozone therapy
  4. Platelet-rich plasma therapy (PRP)

What are the advantages of human umbilical cord mesenchymal stem cells?

How are the stem cells collected?

We use only umbilical cord stem cells that are derived exclusively from umbilical cord donations. 

The umbilical cord stem cells from are collected after informed consent has been given by the parent, or parents, and only after the delivery of the baby.

The collection follows strict ethical protocols ensuring the stem cells are from safe, reliable sources using a non-invasive, simple and painless procedure. Once collected, the cord blood is then screened for disease.

How are the stem cells administered?

The stem cells are administered by intravenous and intrathecal injection.

About the Stem Cells Transplant Institute

Costa Rica has one of the best healthcare systems in world and is ranked among the highest for medical tourism.

Using the most advanced technologies, the team of experts at The Stem Cells Transplant Institute believes in the potential of stem cell therapy for the treatment of autonomic neuropathy.

We are committed to providing personalized service and the highest quality of care to every patient. Contact the experts at the Stem Cells Transplant Institute to see if stem cell treatment might help you.

Scientific References:

  1. Verrotti A et al. Autonomic neuropathy in diabetes mellitus. Front. Endocrinol., 01 December 2014 |
  2. Cell Death Discovery (2016) 2, e16055; doi:10.1038/cddiscovery.2016.55; published online 11 July 2016 Mesenchymal stem cells to treat diabetic neuropathy: a long and strenuous way from bench to the clinic JY Zhou
  3. Han, JW et al., Bone Marrow-Derived Mesenchymal Stem Cells Improve Diabetic Neuropathy by Direct Modulation of Both Angiogenesis and Myelination in Peripheral Nerves. Cell transplant.2016;25(2):313-26. doi: 10.3727/096368915X688209. Epub 2015 May 13
  4. Le PH et al., Autologous Mesenchymal Stem Cell Therapy Delays the Progression of Neurological Deficits in Patients With Multiple System Atrophy. Clinical Pharmacology & Therapeutics (2008). 83. 5, 723-730.
  5. JY Zhou, Z Zhang, and GS Qian, Mesenchymal stem cells to treat diabetic neuropathy: a long and strenuous way from bench to the clinic. Cell Death (2016), 2, e16055; doi:10.1038/cddiscovery.2016.55 Official journal of the Cell Death Differentiation Association