Proximal Neuropathy

Diabetic neuropathies are characterized by damage to the nerves. There are four types of neuropathy; peripheral, proximal, focal, and autonomic. Proximal neuropathy is nerve damage to your hip, buttock or thigh.

Treatment at the Stem Cells Transplant Institute could help improve the symptoms of proximal neuropathy including:

  • Sudden pain in your hip, thigh or buttock
  • Loss of reflexes in your leg such as the knee-jerk reflex
  • Weakness in the leg or legs making it difficult to stand
  • Loss of muscle tissue
  • Unexplained weight loss

What is diabetic proximal neuropathy?

Over time, high blood sugar and high levels of fats in the blood can damage the small blood vessels that nourish the nerves, leading to nerve damage.

Also called femoral neuropathy, diabetic amyotrophy, lumbosacral radiculoplexus or diabetic neuropathic cachexia, diabetic proximal neuropathy is a rare and disabling condition characterized be severe and sometimes disabling pain in your hip, buttock or thigh.

Typically, it presents only on one side of the body but overtime will symptoms will worsen and affect both sides of the body.

What do we know about proximal neuropathy?

Diabetic proximal neuropathy is one of the most unusual forms of neuropathy. Frequently it starts so abruptly the patient knows the exact day the symptoms started.

Typically, in the beginning, the pain presents only on one side of the body, but over time, both legs become involved and the pain can be sharp or deep or burning.

Initially, patients will present with weak thigh muscles and no knee reflexes but will still have reflexes in their ankles. In the later stages, the lower limbs are also affected and patients experience widespread weakness and lose their reflexes in their ankles as well.

What are the challenges?

Most patients will recover from proximal neuropathy within a few years however, they will have residual weakness.

Because patients usually improve overtime, frequently without treatment, physicians underappreciate the pain and suffering caused by the condition.

Most patients will at some point be confined to a wheelchair and unable to work before the symptoms resolve.

Proximal neuropathy can be difficult to diagnose because the symptoms mimic those of other, more common conditions, leading to misdiagnosis.

How can stem cell therapy improve the symptoms of proximal neuropathy?

Mesenchymal stem cells produce;

  1. proteins that support the growth and survival of neurons
  2. angiogenic factors that are essential for the healing, growth, development, and maintenance of blood vessels
  3. immunomodulatory substances that can reverse the damage to the nerves

What is the treatment protocol for proximal neuropathy at the Stem Cells Transplant Institute?

The Stem Cells Transplant Institute recommends the use of hUC-MSCs for the treatment of neuropathy.

Treatment includes:

  1. 1cc vial of 30 million mesenchymal stem cells derived from human umbilical cord blood
  2. Antioxidant therapy with vitamin C and glutathione
  3. Ozone therapy
  4. Platelet-rich plasma therapy (PRP)

What are the advantages of human umbilical cord mesenchymal stem cells?

  • Abundant supply containing up to 10 times more stem cells than bone marrow or adipose derived stem cells
  • hUC-MSC have immunosuppressors and immunomodulatory properties that allow their use in any individual without rejection- Human Leukocyte Antigen (HLA) matching is not necessary
  • Greater proliferation ability than adult autologous stem cells
  • They regenerate at a very rapid rate
  • They are young and very adaptive
  • They have not been impacted by the aging process
  • They have not been affected by environmental toxins
  • Umbilical cord stem cells can be administered multiple times over the course of days
  • Eliminates the need to collect stem cells from the patient’s fat or hip bone reducing pain and recovery time

How are the stem cells collected?

We use only umbilical cord stem cells that are derived exclusively from umbilical cord donations. 

The umbilical cord stem cells from are collected after informed consent has been given by the parent, or parents, and only after the delivery of the baby.

The collection follows strict ethical protocols ensuring the stem cells are from safe, reliable sources using a non-invasive, simple and painless procedure. Once collected, the cord blood is then screened for disease.

How are the stem cells administered?

The stem cells are administered directly into the site of damage and by intravenous injection.

About the Stem Cells Transplant Institute

Costa Rica has one of the best healthcare systems in world and is ranked among the highest for medical tourism.

Using the most advanced technologies, the team of experts at The Stem Cells Transplant Institute believes in the potential of stem cell therapy for the treatment of neuropathy.

We are committed to providing personalized service and the highest quality of care to every patient.

Contact the experts at the Stem Cells Transplant Institute to see if stem cell treatment might help you.

 

Scientific References:

  1. Cell Death Discovery (2016) 2, e16055; doi:10.1038/cddiscovery.2016.55; published online 11 July 2016 Mesenchymal stem cells to treat diabetic neuropathy: a long and strenuous way from bench to the clinic JY Zhou
  2. Han, JW et al., Bone Marrow-Derived Mesenchymal Stem Cells Improve Diabetic Neuropathy by Direct Modulation of Both Angiogenesis and Myelination in Peripheral Nerves. Cell transplant.2016;25(2):313-26. doi: 10.3727/096368915X688209. Epub 2015 May 13