Critical limb ischemia is a serious form of peripheral artery disease, with a 12% rate of amputation within 1 year of diagnosis, and a 50% mortality rate at 5 years of diagnosis.2
Critical limb ischemia is the most severe form of peripheral artery disease.
Peripheral arterial disease occurs when atherosclerosis, the buildup of plaque, causes a narrowing, or blocking of the blood vessels in the peripheral arteries.
Plaque is caused by the presence of cholesterol, calcium, fat and other substances in the blood.
When plaque builds up in the arteries, they harden and weaken, and can no longer send enough blood flow to the extremities, usually the legs.
Critical limb ischemia is associated with a high risk of amputation, myocardial infarction, and death, with mortality rates of 20% within 6 months of initial diagnosis and 50% at 5-years2.
Critical limb ischemia is associated with a poor quality of life and high treatment costs. Stem cell therapy at the Stem Cells Transplant Institute may be a good alternative for patients seeking a safe, non-surgical treatment for critical limb ischemia.
The standard treatment for critical limb ischemia is surgical or endovascular revascularization. Up to 30% of patients do not qualify for treatment because of risks associated with treatment, meaning prognosis for these patients is poor.3
Stem cell transplantation uses healthy cells to promote the repair of damaged cells and regeneration of healthy and functional cells.1
The therapeutic effect of stem cell transplantation in patients with critical limb ischemia may be due to the paracrine effect.
The paracrine effect theory is, transplanted stem cells repair damaged tissue by releasing factors that promote regeneration of healthy stem cells, reduce inflammation, promote the growth of new blood vessels, inhibit cell death, and reduce hypertrophy.1
Animal and human trials have shown stem cell transplantation to be safe and effective in patients with critical limb ischemia.
Research has shown stem cell therapy, in critical limb ischemia, resulted in:3,4
Stem cell therapy cannot help all patients with critical limb ischemia, but for many patients, stem cell therapy, combined with lifestyle modification, may be a safe, effective, non-surgical treatment alternative.
For optimal results, the Stem Cells Transplant Institute recommends the use of hUC-MSCs for the treatment of critical limb ischemia.
If the patient prefers, autologous mesenchymal stem cells derived from the patient’s own adipose tissue and bone marrow, can also be used to treat peripheral artery disease.
Our clinic focuses on obtaining healthy stem cells exclusively from umbilical cord blood donors. We collect the placenta once the baby is born, with the parent’s informed consent. Additionally, we follow strict ethical guidelines and collect stem cells from reliable and reputable sources.
Our nursing staff administers the stem cells through an intravenous and intra-pulmonary route. For the most effective outcomes, intravenous administration is preferred.
Our clinic is located in Costa Rica, which is one of the most popular medical tourism destinations for stem cell therapy. At the Stem Cells Transplant Institute, we have a skilled team of doctors and medical professionals who collect and administer stem cells to treat autism and other conditions. Every patient receives the most cost-effective and top-notch care from our dedicated team.