Neuropathies are characterized by damage to the nerves. There are three types of neuropathy; peripheral, cranial and autonomic. Cranial neuropathy occurs when one or more of the twelve nerves that exit the brain are damaged. The symptoms of cranial neuropathy will depend on which nerve is affected.

Transplantation of stem cells is a very promising approach for the treatment of different neuropathies.  Treatment at the Stem Cells Transplant Institute could help improve the symptoms of cranial neuropathy including:

  • Sharp, jabbing or throbbing pain
  • Drooping of the facial muscle
  • Tingling
  • Numbness
  • Loss of vision
  • Double vision
  • Abnormal movement of the eye
  • Blurred vision
  • Increased pupil size
  • Droopy eyelid
  • Weak or paralyzed muscles
  • Skin that is sensitive to touch

What is cranial neuropathy?

Neuropathy is a general term to used describe any condition that results in damage to one or more nerves. Injury or disease can damage the nerves at any location and the type of neuropathy is typically classified by the location of the damaged nerves or by the disease causing the damage. Cranial neuropathy occurs when one or more of the twelve nerves that exit the brain, or brain stem, are damaged.

Types of cranial neuropathies include:

  • Bell’s palsy.This condition occurs when the facial nerve, or seventh cranial nerve, is affected.
  • Microvascular cranial nerve palsy.This condition affects the nerves in the eye. It is most common in people who have diabetes and in those who have high blood pressure.
  • Third nerve palsy.This condition affects the third cranial nerve. This nerve helps manage a muscle that controls eye movement.
  • Fourth nerve palsy.This is also called superior oblique palsy. It affects the superior oblique muscle, which helps you converge your eyes (to look at the tip of your nose).
  • Sixth nerve palsy.This is also called cranial nerve VI or abducens palsy. It affects the sixth cranial nerve, which also helps control eye movement.
  • Multiple cranial neuropathies: several different cranial nerves are affected

Possible causes of cranial neuropathy include:

  • Diabetes
  • High blood pressure
  • Migraine headaches
  • Infections
  • Inherited disorders
  • Tumor
  • Trauma
  • Virus

Can stem cell therapy improve symptoms of?

Sometimes medicines can be used to treat an infection, help reduce swelling in or near a nerve, or help if the neuropathy is causing pain. In some cases, surgery may help. Other times, the nerve damage can’t be treated or repaired.

Mesenchymal stem cells produce; 1. proteins that support the growth and survival of neurons, 2. angiogenic factors that are essential for the healing, growth, development, and maintenance of blood vessels, and 3. immunomodulatory substances that can reverse the damage to the nerves.1,2 

In 2014, researchers published the results of a study using autologous adipose derived stem cells to treat patients with neuropathic facial pain.  Results showed treatment with stem cells was safe and drastically decreased the pain intensity up to 6 months.1

What type of stem cells are used?

The Stem Cells Transplant Institute uses autologous adipose derived mesenchymal stem cells for the treatment of neuropathy.  Autologous means the stem cells are collected from the recipient so the risk of rejection is virtually eliminated. Mesenchymal stem cells are one type of adult stem cells that are found in a variety of tissues including; adipose tissue, lung, bone marrow, and blood.  There are large numbers of stem cells in subcutaneous adipose tissue, and this tissue is easy to obtain without a painful procedure, Mesenchymal stem cells are a promising treatment for neuropathy. Treatment at the Stem Cells Transplant Institute may improve the symptoms of cranial neuropathy.

How are the stem cells collected?

A team of stem cell experts developed an FDA approved method and protocol for harvesting and isolating adipose derived stem cells for autologous reimplantation. The collection and use of adult stem cells does not require the destruction of embryos and for this reason, more U.S. federal funding is being spent on stem cell research.

How are the stem cells administered?

The stem cells are administered by intravenous and intrathecal injection.

About the Stem Cells Transplant Institute

Costa Rica has one of the best healthcare systems in world and is ranked among the highest for medical tourism. Using the most advanced technologies, the team of experts at The Stem Cells Transplant Institute believes in the potential of stem cell therapy for the treatment of neuropathy. We are committed to providing personalized service and the highest quality of care to every patient. Contact the experts at the Stem Cells Transplant Institute to see if stem cell treatment might help you.



1Cell Death Discovery (2016) 2, e16055; doi:10.1038/cddiscovery.2016.55; published online 11 July 2016 Mesenchymal stem cells to treat diabetic neuropathy: a long and strenuous way from bench to the clinic JY Zhou 2. Vickers RE et al., A preliminary report on stem cell therapy for neuropathic pain in humans. J Pain Res. 2014; 7: 255–263. Published online 2014 May 8.

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