Stem cells Transplant Institute in Costa Rica, under the direction of Dr. Mesén, is a pioneer in the use of Stem Cells Therapies in Costa Rica. At Stem Cells Transplant Institute, we use adult autologous stem cells for the treatment of Alzheimer´s disease.
Stem cells are being scrutinized as a potential therapeutic tool to prevent Alzheimer’s disease. In vitro work investigations to examine the potential impact of cord blood-derived mesenchymal stem cells treatment on neuronal loss, confirmed that cord blood-derived mesenchymal stem cells reduced the hippocampal apoptosis (cellular programmed death) induced by amyloid-β peptide. Moreover, in an acute Alzheimer’s disease, it has been demonstrated that markers of glial activation, oxidative stress and apoptosis levels were decreased in the brain. Investigations suggest that stem cells warrant further investigation as a potential therapeutic agent in Alzheimer´s disease.
Transplantation of Stem Cells at sites of neuronal degeneration is a very promising approach for the treatment of different neurological diseases such as Alzheimer`s Disease, as they can be expanded in culture, thus avoiding many of the practical obstacles that limit the application of transplanting primary neurons. It has already been shown that human Neural Stem Cells transplanted into brains can differentiate into neural cells and significantly improve the cognitive functions, further pointing to Neural Stem Cells as a promising candidate for neuroreplacement therapies.
Using stem cell therapies offered at Stem Cells Transplant Institute, you could improve symptoms and signs of Alzheimer´s disease such as:
- Lost of recent memories
- Social withdrawal
- Mood swings
- Distrust in others
- Irritability and aggressiveness
- Changes in sleeping habits
Currently, Alzheimer´s Disease therapy is only used to reduce the degree of impairment and to improve the quality of life, but the disease cannot be prevented or cured. The demonstration of active adult neurogenesis has since opened possibilities of repairing the mature Central Nervous System after degenerative neurological diseases like Alzheimer´s Disease. Ongoing research promises a bright future for the clinical application of Neural Stem Cell strategies in neuro-replacement therapy for Alzheimer´s disease patients, and may potentially reverse the progression of the disease.
Alzheimer´s disease is the commonest cause of dementia affecting older people. Affects nearly 2% of the population in industrialized countries. Alzheimer´s disease is a progressive neurodegenerative disorder, pervasive in the aging population.
The risk of Alzheimer´s disease increases dramatically in individuals beyond the age of 70 and it is predicted that its incidence will increase threefold within the next 50 years.
Alzheimer´s disease results from a continuous loss of neurons, mainly in the entorhinal or paraentorhinal cortex and hippocampus. This progressive loss is preceded by a destruction of synapses (connections between neurons) and axonal damage. Neurodegeneration is accompanied by an activation of brain´s defense-cells and an abnormal increase in the number of astrocytes (cells that provide physical support to neurons and clean up debris within the brain). It results in a chronic, pro-inflammatory state. The disease starts with a mild cognitive impairment and progresses toward more severe decline and, eventually, dementia.
In recent years it has been noted that the adult brain has the ‘self-repair capacity’ to replace lost neurons in several selected regions of the central nervous system.
Neural Stem cells within these neurogenic regions can proliferate and differentiate into neurons or glia, providing a reservoir for replacement of cells lost during normal cell turnover and after brain injury. Neurogenesis involves the self-renewal and proliferation of neural stem cells, as well as its differentiation into neurons and glia. Newborn neurons and glia then migrate to appropriate regions in the brain and integrate into neuronal circuits.
In the early stages of Alzheimer’s disease there is a relatively discrete population of neurons affected. Thus, the disease offers a relatively discrete target for potential therapies making it an ideal target for cell replacement therapy using endogenously activated Neural stem cells. It has been suggested that mobilizing endogenous stem cells already present in the brain or transplantation of exogenous cells to replace lost cells, may be a realistic therapeutic approach.
Mesenchymal stem cell subpopulations express a variety of neuro-regulatory molecules and promote neuronal cell survival. Neural Stem Cells transplanted at sites of nerve injury are thought to promote functional recovery by producing trophic factors that induce survival and regeneration of host neurons.
Nowadays, physicians are with an eye towards the development of Neural Stem Cells replacement therapies.
Stem Cells Transplant Institute in Costa has state-to-the-art technologies and human resource to help you get fascinating treatment possibilities for Alzheimer´s disease through the use of stem cells. Costa Rica ranks as one of the best healthcare systems in the World, we offer high-quality stem cells treatments for just a fraction of the price you get in the USA. Don´t hesitate to contact us.