Neurodegeneration is the progressive loss of structure and/or function of neurons including death. Neurodegenerative diseases include; Alzheimer’s disease, Parkinson’s disease and Huntington’s disease.
Alzheimer’s disease (AD) is the most common cause of dementia and is responsible for 60-80 percent of dementia cases.
The Stem Cells Transplant Institute recommends the use of mesenchymal stem cells, derived cultured, and expanded from umbilical cord tissue, for the treatment of neurological diseases including Alzheimer’s disease.
Dementia is a fatal disease characterized by chronic inflammation and neuronal loss resulting in amnesia, progressive cognitive impairment, and disorientation.
Alzheimer’s disease is the most common form of dementia with more than 5 million people in the United States living with this devastating disease, and it is the 6th leading cause of death, killing more people than prostate cancer and breast cancer combined.1.
The exact cause of Alzheimer’s disease is unknown but there are four key features; 1. Amyloid-beta (Aß) plaques, 2. Neurofibrillary tangles, 3. Neuroinflammation, and 4. Mass neuronal and synaptic loss. Amyloid-beta plaques are sticky clumps of protein fragments that accumulate and attack brain cells, leading to their death. Neurofibrillary tangles are twisted fibers of Tau protein that build up inside the neurons of Alzheimer’s patients damaging neural structures and inhibiting the transport of nutrients. Neuroinflammation is caused by the activation of microglia which mediate immune responses. Microglia are activated and begin producing cytokines that increase neuroinflammation. All of these factors result in mass neuronal and synaptic loss causing the cortex region of the brain to atrophy, or decrease in size.3-7
Human umbilical cord mesenchymal stem cells (hUC-MSCs) can promote the release of acetylcholine, promote neurogenesis and synaptic formation and can reduce oxidative stress and cell death. Research is showing hUC-MSCs to be a better alternative to allogeneic stem cells because of their hypo-immunogenicity, superior tropism, high differentiation potential and paracrine activity.10-13
Evidence suggests HUC-MSCs can differentiate into a variety of neuro-regulatory molecules and can elevate several factors including brain-derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF), insulin-like growth factor 1 (IGF-1), Glucagon-like pepetide-1 (GLP-1), and vascular endothelial growth factor (VEGF).9
Neural stem cells transplanted at sites of nerve injury are thought to promote functional recovery by producing trophic factors that induce survival and regeneration of host neurons. Intravenously administered mesenchymal stem cells are also capable of crossing the blood-brain barrier and effectively migrating to regions of neural injury, without inducing tumor growth or an immune response.9
Research has shown mesenchymal stem cells have the potential to affect Alzheimer’s through multiple pathways and can:
According ClinicalTrials.gov (https://clinicaltrials.gov) on March 18, 2019, the safety and efficacy results from animal models has led to the following five trials evaluating the safety and efficacy of hUC-MSC transplantation in patients diagnosed with Alzheimer’s disease.
Safety and Efficiency of Umbilical Cord-derived Mesenchymal Stem Cells (UC-MSC) in Patients With Alzheimer’s Disease
Biological: Human Umbilical Cord Derived MSC
Safety and Exploratory Efficacy Study of UCMSCs in Patients With Alzheimer’s Disease
Safety and Exploratory Efficacy Study of NEUROSTEM® Versus Placebo in Patients With Alzheimer’s Disease
Biological: human umbilical cord blood derived mesenchymal stem cells
Other: Normal saline 2mL
No Results Available
The Stem Cells Transplant Institute recommends the use of hUC-MSCs for the treatment of Alzheimer’s disease. For optimal results, we recommend Aggressive Platinum Therapy (APT). APT is a 4-day treatment plan.
Each day you will receive the following:
Alzheimer’s disease destroys many different types of neurons in the brain.Successful treatment requires all the stem cells to travels to and differentiate into different types of neurons and other brain cells correctly.At this time stem cell therapy does not stop the underlying cause of Alzheimer’s disease and patient may need more than one treatment due to a declining effect over time
Our clinic focuses on obtaining healthy stem cells exclusively from umbilical cord blood donors. We collect the placenta once the baby is born, with the parent’s informed consent. Additionally, we follow strict ethical guidelines and collect stem cells from reliable and reputable sources.
Our nursing staff administers the stem cells through an intravenous and intra-pulmonary route. For the most effective outcomes, intravenous administration is preferred.
Our clinic is located in Costa Rica, which is one of the most popular medical tourism destinations for stem cell therapy. At the Stem Cells Transplant Institute, we have a skilled team of doctors and medical professionals who collect and administer stem cells to treat autism and other conditions. Every patient receives the most cost-effective and top-notch care from our dedicated team.