A study published on March 18, 2019, by the Proceedings of the National Academy of Sciences (PNAS), found that increases in chronic inflammation, not the passage of time, is the main reason why injured bones do not heal as well with age.
Stem cells can give rise to any tissue found in the body and, as a result, can provide a nearly limitless potential for medical applications. Current studies are researching how stem cells may be used to replace or repair bone tissue damaged by disease or injury.
Frailty, or diseases that weaken the skeleton, is one of the leading causes of age-related disabilities in the United States. Fatalities due to bone fractures alone are low, but bone fractures can greatly diminish a person’s quality of life and for some, the fractures never completely heal.
The inability to heal or the slower rate of healing is due to age-associated inflammation, called ‘inflamm-aging‘, which causes a decline in the total number, and overall function, of skeletal stem cells. It is the skeletal stem cells that enable bones to heal.
The Stem Cells Transplant Institute in Costa Rica offers high quality Stem Cells Therapies to treat bone disease.
About the Study
The study shows that the breakdown of the protein machines and large molecules produce remnants which trigger the immune system. Although the immune system mainly helps destroy invading microbes, this system can also react to the body’s own proteins and cause inflammation to fight infection at the site of injury and help aid in the healing process.
The study published by PNAS explains how aging can increase immune signals that diminish the ability of stem cells to multiply, resulting in fewer skeletal stem cells in older people. A reduced number of skeletal stem cells compromises the body’s ability to make new bone after a fracture.
It’s Not the Number of Years
The total number of stem cells in the bone marrow declines significantly with age, resulting in fractures needing more time to heal. The recent study explored the related mechanisms that may cause a reduction in stem cells as we age.
Researchers found that, by exposing young stem cells to blood serum with older stem cells, they were able to indirectly activate a key immune-related protein. That protein interacts with DNA, and by activating that protein, they turned on several pro-inflammatory genes which resulted in skeletal stem cells to stop multiplying.
Stem Cells & Anti-inflammatory drugs
Additional studies showed that anti-inflammatory treatment changed the action of thousands of genes in the stem cells, restoring them to a genetic profile seen in young skeletal stem cells.
This result suggests that administering stem cells and anti inflammatory drugs during the weeks prior to elective orthopedic surgeries, such as hip or knee replacements, would be a superior treatment to current treatment protocols. The combination of stem cells and anti-inflammatory drugs seems to be a promising therapy.
Stem Cells Transplant Institute
Stem cell therapy at the Stem Cells Transplant Institute helps to regulate the immune system response, inhibit inflammation, stimulate blood vessel growth, repair tissue, and stimulate self-regeneration of the cartilage and bone.
Therapy can be used for the treatment of osteoarthritis, bone injury, chronic pain and other conditions that currently have very limited treatment options.
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