Does Gum Disease Cause Alzheimer’s Disease?

Gum Disease alzheimer's

Does Gum Disease Cause Alzheimer’s Disease?

The answer to this question is still unclear but new research shows the bacteria associated with chronic gum disease, Porphyromonas gingivalis (Pg) is present in the brains of patients diagnosed with Alzheimer’s disease. For several years poor oral health has been associated with Alzheimer’s disease but it has not been clear whether gum disease causes Alzheimer’s disease or is a result of Alzheimer’s disease.

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The results of a study, sponsored by Cortexyme Inc., a startup biotech company is San Francisco, were published in the January issue of Science Advances. The results confirmed the bacteria Pg, that cause gum disease, are present in the brains and spinal fluid of patients with Alzheimer’s disease.

Researchers from Cortexyme worked with physicians and labs around the world including Europe, New Zealand, Australia and the United States to evaluate the brains of more than 50 deceased patients with a confirmed diagnosis of Alzheimer’s disease. They found the bacteria Pg was present in more than 90 percent of the samples. In addition, they detected the bacteria in the spinal fluid of living patients that had also been diagnosed with Alzheimer’s disease.

Following these results, the team of researchers conducted animal studies, and found that when mice were given an oral Pg infection, the bacteria was also found in the brain of the animal and it led to an increased production of amyloid beta, which is a component of the amyloid plaques associated with Alzheimer’s disease.

The authors of the paper state more research needs to be conducted before any firm conclusions are made, but the research suggests that the oral bacteria causes Alzheimer’s disease. The company is hoping results of this research will lead to new treatments in the future.

Currently in many areas of the world, experts in the field of regenerative medicine are using stem cell therapy to successfully treat patients with Alzheimer’s disease. At the Stem Cells Transplant Institute, we use umbilical cord derived mesenchymal stem cells for the treatment of Alzheimer’s disease.

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Aging and age-related diseases are the result of aging stem cells. For maximum results from stem cell therapy it is better to use young, agile and more adaptable cells. Contact us today to learn more about the benefits of stem cell therapy at the Stem Cells Transplant Institute.


Journal Reference:

  1. Stephen S. Dominy et al. Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitorsScience Advances, 2019

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