Synovial joints facilitate mobility by allowing bones to articulate with one another. In synovial joints, the bones are covered by hyaline articular cartilage that minimizes the forces that the non-deformable bones
are subjected to bearing. Each synovial joint contains a vascularized synovium and enclosed by a tough fibrous capsule.
Osteoarthritis is a leading cause of pain and disability and leads to a reduced quality of life. Osteoarthritis is the most prevalent form of arthritis and can affect any synovial joint in the body. The joints most commonly affected are hands, hips, knees, and spine. The disease is characterized by failed and/or aberrant repair of damaged joint tissue, which usually begins in focal areas and expands over time.
Osteoarthritis generates a painful joint condition that affects more than 8 million people and there is currently no effective drug therapy or treatment to prevent it or slow down its progression. Current treatment of knee Osteoarthritis is associated with limitations and side effects that restrict their ability to effectively treat the symptoms of the condition and stop its progression.
Therapies involving the use of tissue-specific cells present a promising alternative in the treatment of degenerative diseases and injures. Stem cells are being studied in the treatment of osteoarthritis, with the aim of repairing damage to the joint, stopping the condition getting worse and delaying, or even avoiding, the need for knee replacement surgery.
Stem cells have anti-inflammatory and regenerative capacities. Some stem cells have been shown to regulate the immune system response, inhibit inflammation, stimulate blood vessel formation, repair tissue and help transplanted stem cells to engraft. Stem cells can also make cartilage.
Skeletal tissue regeneration is being addressed for a number of common clinical conditions including repair of non-healing fractures and bone defects through transplantation of skeletal stem cells (mesenchymal stem cells).
Transplanted mesenchymal stem cells do not lead to graft rejection and they are easily collected from bone marrow, fat, and umbilical cord.
Pre-clinical studies transplanting chondrocytes made from mesenchymal stem cells into animals with osteoarthritis and Rheumatoid arthritis have proven benefits, and the evolution to clinical trials is promising.
Recent research has demonstrated that Human adipose-derived stem cells are safe for use in humans and can differentiate into cartilage and bone, suggesting a potential treatment in osteoarthritis. Stem cells therapy consists of the direct administration of the cells into the affected joint. Cells can also be introduced intravenously.
The Stem Cells transplant institute aim to provide you with the highest quality equipment and human resource for you to get into these innovating therapies in a safe and trustworthy way.