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Neuropathy is a condition that develops as a result of damage to the peripheral nervous system, an estimated 20 million people in the United States have some form of peripheral neuropathy. Neuropathy means nerve disease

Neuropathy is a condition that develops as a result of damage to the peripheral nervous system, an estimated 20 million people in the United States have some form of peripheral neuropathy.

Neuropathy means nerve disease or damage. Symptoms can range from numbness or tingling, to pricking sensations, or muscle weakness. Severe symptoms may include burning pain, muscle wasting, paralysis, or organ dysfunction. In the most extreme cases, breathing may become difficult, or organ failure may occur.

Peripheral neuropathies can present in a variety of forms and follow different patterns. Symptoms may be experienced over a period of days, weeks, or years. They can be acute or chronic.

Diabetic neuropathy is the most common form of peripheral neuropathy, nerve damage usually is bilateral and occurs in an ascending pattern. The conventional treatments are glucose control and pain management.

Investigations show that bone marrow-derived mesenchymal stem cells may improve diabetic neuropathy by direct modulation of both angiogenesis (the physiological process through which new blood vessels form) and myelination (process of forming a myelin sheath around a nerve to allow nerve impulses to move more quickly).

Stem cells are a promising source of tissue engineering due to their differentiation potential. Today, direct transplantation of stem cells for cell therapy is commonly performed.

Transplantation of autologous human adipose stem cells improved mechanical pain and enhanced functional recovery in a rat model of neuropathic pain.

Mesenchymal stem cells are self-renewing cells that can be found in almost all postnatal organs and tissues, they are most frequently isolated from bone marrow, but depending on their intended purpose, experimental or therapeutic use, mesenchymal stem cells can be isolated from adipose tissue, umbilical cord blood, compact bone, and other tissues. Studies in animals have show that early transplantation of bone marrow-derived mesenchymal stem cells after spinal cord injury, increases locomotor function and decreases pain hypersensitivity to mechanical and thermal stimulation.

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