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Systemic lupus erythematosus is an autoimmune disease characterized by the production of autoantibodies, which results in widespread immunologic abnormalities and immune complex formation. The immune

system attacks the normal cells and tissues in the body causing dysfunction of many organs like skin, kidney, hearth and lungs.

Systemic lupus erythematous is a disease with highly varied clinical presentations that could significantly affect the patient’s life of quality and make them dependent of treatment.

The treatment of severe autoimmune diseases has been recently revitalized by autologous hematopoietic stem cell transplantation using either marrow or peripheral blood. Current trials suggest that these therapies can induce remission of the disease by “rebooting” the immune system, which results in regulation and modulation of the immunological system in addition to a decrease of the inflammatory response. It is also possible that autologous hematopoietic stem cell transplantation may prolong the life of patients with otherwise high-risk features.

Late stages of the disease, when progressing toward kidney failure, represent a serious public health problem. To find an alternative proposal for kidney replacement, the induced pluripotent stem cells technology was adopted. Some studies support that use of induced pluripotent stem cells results in reprogramming of urine-derived renal tubular cells. Also it has been proven that generation of Systemic lupus erythematosus specific induced pluripotent stem cells is feasible and efficient. Stem cells would also provide convenient model to study disease pathogenesis, drugs screening, and gene therapy.

Mesenchymal stem cells are now known to display not only adult stem cell multipotency but also robust anti-inflammatory and regenerative properties.

There is much to be learned from the basic and clinical science of mesenchymal stem cells in order to reap the full potential of these multifaceted progenitor cells in the treatment of autoimmune diseases, but so far results are very positive and promising. In The Stem Cells transplant institute, we believe in the potential of these therapies and we offer you a secure and trustworthy environment for you to explore this treatment modality.

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