Diabetes mellitus, which affects 346 million people, is one of the leading causes of death worldwide. Pancreatic β cells play a central role in the progression of diabetes.
In addition, pancreas or islet transplantation has been used to treat type 1-diabetes patients.
Developing efficient strategies to derive functional pancreatic β cells is important for both cell replacement therapy and disease modeling of diabetes. Induced pluripotent stem cells and adult pancreatic stem/progenitor cells, are used to generate functional pancreatic β cells.
Several recent studies have suggested that the adult bone marrow stem cells can influence β-cell regeneration in diabetic animals. It has been also shown that bone marrow cells and mesenchymal stem cells when are concomitantly administrated into diabetic mice, blood glucose and serum insulin concentrations rapidly returned to normal levels, accompanied by efficient tissue regeneration after a single injection.
Bone marrow cells and allogeneic mesenchymal stem cells induce the regeneration of pancreatic insulin-secreting cells. Also, mesenchymal stem cells inhibit T-cell-mediated immune responses against newly formed β-cells, which, in turn, are able to survive. Thus, the application of this therapy in human patients suffering from diabetes and/or other tissue destructive autoimmune diseases appears to be feasible.
Diabetic skin has impaired wound-healing properties following injury. Treatment with mesenchymal stem cells may improve diabetic wound healing by increasing collagen content, and correcting the impaired biomechanical properties of diabetic skin.
Diabetic neuropathy is the most common form of peripheral neuropathy, nerve damage usually is bilateral and occurs in an ascending pattern. The conventional treatments are glucose control and pain management.
Investigations show that bone marrow-derived mesenchymal stem cells may improve diabetic neuropathy by direct modulation of both angiogenesis (the physiological process through which new blood vessels form) and myelination (process of forming a myelin sheath around a nerve to allow nerve impulses to move more quickly).
The Stem Cells transplant institute aims to provide you with the highest quality equipment and human resource for you to get into these innovating therapies in a safety and trustworthy way.