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Tissue specific stem cells were identified in adult stromal tissues. Ultraviolet radiation induces photo-aging on human skin. Because of UVA irradiation, it is thought that aging phenomenon such as skin elasticity reduction, wrinkle

Tissue specific stem cells were identified in adult stromal tissues. Ultraviolet radiation induces photo-aging on human skin. Because of UVA irradiation, it is thought that aging phenomenon such as skin elasticity reduction, wrinkle formation, and retardation of wound healing occurs. Studies demonstrated the reduction of human dermal stem cells functionality by UVA irradiation.

Endothelial dysfunction is associated with major causes of morbidity and mortality, as well as numerous age-related conditions. The possibility of preserving or even rejuvenating endothelial function offers a potent means of preventing/treating some of the most fearful aspects of aging such as loss of mental, cardiovascular, and sexual function.

Endothelial stem cells provide a continual source of replenishment for damaged or senescent blood vessels. Endothelial stem cells act as an endogenous mechanism of regeneration. Therapeutic interventions based on mobilization of endothelial stem cells are very promising.

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